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1

COX-dependent mechanisms involved in the antinociceptive action of NSAIDs at central and peripheral sites

Maria Burian, Gerd Geisslinger

Journal:

Pharmacology & Therapeutics

Year:

2005

Language:

english

File:

PDF, 260 KB

english, 2005

2

Pathophysiological mechanisms of neuropathic pain

Vollert, Jan, Magerl, Walter, Baron, Ralf, Binder, Andreas, Enax-Krumova, Elena K, Geisslinger, Gerd, Gierthmühlen, Janne, Henrich, Florian, Hüllemann, Philipp, Klein, Thomas, Lötsch, Jörn, Maier, Chr

Journal:

Year:

2018

Language:

english

File:

PDF, 618 KB

english, 2018

3

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype

Andreas Weigert, Susanne Schiffmann, Divya Sekar, Stephanie Ley, Heidi Menrad, Christian Werno, Sabine Grosch, Gerd Geisslinger, Bernhard Brüne

Journal:

International Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 466 KB

english, 2009

4

Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers*

Lötsch, Jörn, Stockmann, Anne, Kobal, Gerd, Brune, Kay, Waibel, Rainer, Schmidt, Norbert, Geisslinger, Gerd

Journal:

Clinical Pharmacology & Therapeutics

Year:

1996

Language:

english

File:

PDF, 984 KB

english, 1996

5

Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome

Carsten Skarke, Helmut Schmidt, Gerd Geisslinger, Jutta Darimont, Jörn Lötsch

Journal:

British Journal of Clinical Pharmacology

Year:

2003

Language:

english

File:

PDF, 114 KB

english, 2003

6

Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages

Geethanjali Pickert, Hee-Young Lim, Andreas Weigert, Annett Häussler, Thekla Myrczek, Maximilian Waldner, Sandra Labocha, Nerea Ferreirós, Gerd Geisslinger, Jörn Lötsch, Christoph Becker, Bernhard Brü

Journal:

International Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 3.03 MB

english, 2012

7

Dimethylcelecoxib inhibits prostaglandin E2 production

Ivonne Wobst, Susanne Schiffmann, Kerstin Birod, Thorsten J. Maier, Ronald Schmidt, Carlo Angioni, Gerd Geisslinger, Sabine Grösch

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 601 KB

english, 2008

8

Structure–Activity Relationship of Nonacidic Quinazolinone Inhibitors of Human Microsomal Prostaglandin Synthase 1 (mPGES 1)

Rörsch, Florian, Buscató, Estel.la, Deckmann, Klaus, Schneider, Gisbert, Schubert-Zsilavecz, Manfred, Geisslinger, Gerd, Proschak, Ewgenij, Grösch, Sabine

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.22 MB

english, 2012

9

Pharmacokinetics of Opioids in Liver Disease

Irmgard Tegeder, Jörn Lötsch, Dr Gerd Geisslinger

Journal:

Clinical Pharmacokinetics

Year:

1999

Language:

english

File:

PDF, 294 KB

english, 1999

10

Peripheral Antihyperalgesic Effect of Morphine to Heat, but Not Mechanical, Stimulation in Healthy Volunteers after Ultraviolet-B Irradiation

Koppert, Wolfgang, Likar, Rudolf, Geisslinger, Gerd, Zeck, Susanne, Schmelz, Martin, Sittl, Reinhard

Journal:

Anesthesia & Analgesia

Year:

1999

Language:

english

File:

PDF, 208 KB

english, 1999

11

Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy

Doehring, Alexandra, Hofmann, Wolf Peter, Schlecker, Christina, Zeuzem, Stefan, Sarrazin, Christoph, Berg, Thomas, Müller, Tobias, Herrmann, Eva, Geisslinger, Gerd, Lötsch, Jörn

Journal:

Pharmacogenetics and Genomics

Year:

2011

Language:

english

File:

PDF, 261 KB

english, 2011

12

Immunogenicity assay development and validation for biologic therapy as exemplified by ustekinumab

Mojtahed Poor, Sorwe, Ulshöfer, Thomas, Gabriel, Laureen A., Henke, Marina, Köhm, Michaela, Behrens, Frank, Geisslinger, Gerd, Parnham, Michael J., Burkhardt, Harald, Schiffmann, Susanne

Journal:

Clinical & Experimental Immunology

Year:

2019

Language:

english

File:

PDF, 1.22 MB

english, 2019

13

UGCG influences glutamine metabolism of breast cancer cells

Schömel, Nina, Hancock, Sarah E., Gruber, Lisa, Olzomer, Ellen M., Byrne, Frances L., Shah, Divya, Hoehn, Kyle L., Turner, Nigel, Grösch, Sabine, Geisslinger, Gerd, Wegner, Marthe-Susanna

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 1.86 MB

english, 2019

14

Pharmacokinetics of ibuprofen enantiomers in dogs

Dr. Winfried S. Beck, Gerd Geisslinger, Heidrun Engler, Kay Brune

Journal:

Year:

1991

Language:

english

File:

PDF, 527 KB

english, 1991

15

The effect of the enantiomers of ibuprofen and flurbiprofen on the β-oxidation of palmitate in the rat

Bin Zhao, Gerd Geisslinger, Iris Hall, Richard O. Day, Kenneth M. Williams

Journal:

Year:

1992

Language:

english

File:

PDF, 521 KB

english, 1992

16

Stereoselectivity of biliary excretion of 2-arylpropionates in rats

Sabine Menzel, Winfried S. Beck, Kay Brune, Gerd Geisslinger

Journal:

Year:

1993

Language:

english

File:

PDF, 554 KB

english, 1993

17

Stereoselective pharmacokinetics of methadone in beagle dogs

Norbert Schmidt, Kay Brune, Kenneth M. Williams, Dr. Gerd Geisslinger

Journal:

Year:

1994

Language:

english

File:

PDF, 306 KB

english, 1994

18

Variability of inversion of (R)-flurbiprofen in different species

Sabine Menzel-Soglowek, Gerd Geisslinger, Winfried S. Beck, Kay Brune

Journal:

Journal of Pharmaceutical Sciences

Year:

1992

Language:

english

File:

PDF, 371 KB

english, 1992

19

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype

Irmgard Tegeder, Jan Adolph, Helmut Schmidt, Clifford J. Woolf, Gerd Geisslinger, Jörn Lötsch

Journal:

European Journal of Pain

Year:

2008

Language:

english

File:

PDF, 325 KB

english, 2008

20

Epigenetics in pain and analgesia: An imminent research field

Alexandra Doehring, Gerd Geisslinger, Jörn Lötsch

Journal:

European Journal of Pain

Year:

2011

Language:

english

File:

PDF, 260 KB

english, 2011

21

Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice

Laura Popp, Annett Häussler, Anke Olliges, Rolf Nüsing, Shuh Narumiya, Gerd Geisslinger, Irmgard Tegeder

Journal:

European Journal of Pain

Year:

2009

Language:

english

File:

PDF, 1.03 MB

english, 2009

22

Determination of 8-methoxypsoralen in human plasma, and microdialysates using liquid chromatography–tandem mass spectrometry

Lutz Bräutigam, Maic Seegel, Irmgard Tegeder, Helmut Schmidt, Silke Meier, Maurizio Podda, Roland Kaufmann, Marcella Grundmann-Kollmann, Gerd Geisslinger

Journal:

Journal of Chromatography B

Year:

2003

Language:

english

File:

PDF, 170 KB

english, 2003

23

LC–MS/MS-analysis of prostaglandin E2 and D2 in microdialysis samples of rats

Ronald Schmidt, Ovidiu Coste, Gerd Geisslinger

Journal:

Journal of Chromatography B

Year:

2005

Language:

english

File:

PDF, 545 KB

english, 2005

24

High sensitive determination of sufentanil in human plasma of parturients and neonates following patient-controlled epidural analgesia (PCEA)

Ronald Schmidt, Dorothee H. Bremerich, Gerd Geisslinger

Journal:

Journal of Chromatography B

Year:

2006

Language:

english

File:

PDF, 498 KB

english, 2006

25

Cerebrospinal fluid prostaglandins after systemic dipyrone intake*

Levy, Micha, Brune, Kay, Zylber-Katz, Ester, Cohen, Oren, Caraco, Yoseph, Geisslinger, Gerd

Journal:

Clinical Pharmacology & Therapeutics

Year:

1998

Language:

english

File:

PDF, 604 KB

english, 1998

26

Pharmacokinetics of morphine-6-glucuronide and its formation from morphine after intravenous administration*

Lötsch, Jörn, Weiss, Michael, Kobal, Gerd, Geisslinger, Gerd

Journal:

Clinical Pharmacology & Therapeutics

Year:

1998

Language:

english

File:

PDF, 1.06 MB

english, 1998

27

Effect of clofibrate on the chiral inversion of ibuprofen in healthy volunteers*

Scheuerer, Stefan, Hall, Stephen D., Williams, Kenneth M., Geisslinger, Gerd

Journal:

Clinical Pharmacology & Therapeutics

Year:

1998

Language:

english

File:

PDF, 924 KB

english, 1998

28

High-performance liquid chromatographic determination of pentazocine in plasma

Norbert Moeller, Klaus Dietzel, Bernd Nuernberg, Gerd Geisslinger, Kay Brune

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1990

Language:

english

File:

PDF, 343 KB

english, 1990

29

Determination of celecoxib in human plasma and rat microdialysis samples by liquid chromatography tandem mass spectrometry

Lutz Bräutigam, Gregor Vetter, Irmgard Tegeder, Georg Heinkele, Gerd Geisslinger

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

2001

Language:

english

File:

PDF, 255 KB

english, 2001

30

A rapid screening method for a single nucleotide polymorphism (SNP) in the human MOR gene

Sabine Grösch, Ellen Niederberger, Jörn Lötsch, Carsten Skarke, Gerd Geisslinger

Journal:

British Journal of Clinical Pharmacology

Year:

2001

Language:

english

File:

PDF, 82 KB

english, 2001

31

Computerized surveillance of adverse drug reactions in hospital: pilot study

Tatyana Azaz-Livshits, Micha Levy, Batami Sadan, Meir Shalit, Gerd Geisslinger, Kay Brune

Journal:

British Journal of Clinical Pharmacology

Year:

1998

Language:

english

File:

PDF, 78 KB

english, 1998

32

Validation of a new fluorogenic real-time PCR assay for detection of CYP2C9 allelic variants and CYP2C9 allelic distribution in a German population

Maria Burian, Sabine Grösch, Irmgard Tegeder, Gerd Geisslinger

Journal:

British Journal of Clinical Pharmacology

Year:

2002

Language:

english

File:

PDF, 90 KB

english, 2002

33

Spatial distribution of 8-methoxypsoralen penetration into human skin after systemic or topical administration

Marcella Grundmann-Kollmann, Maurizio Podda, Lutz Bräutigam, Katja Hardt-Weinelt, Ralf J. Ludwig, Gerd Geisslinger, Roland Kaufmann, Irmgard Tegeder

Journal:

British Journal of Clinical Pharmacology

Year:

2002

Language:

english

File:

PDF, 94 KB

english, 2002

34

Inhibition of Noxious Stimulus-Induced Spinal Prostaglandin E2 Release by Flurbiprofen Enantiomers : A Microdialysis Study

Gerd Geisslinger, Uta Muth-Selbach, Ovidiu Coste, Gregor Vetter, Andreas Schrödter, Hans-Georg Schaible, Kay Brune, Irmgard Tegeder

Journal:

Journal of Neurochemistry

Year:

2000

Language:

english

File:

PDF, 137 KB

english, 2000

35

Effects of selective COX-1 and -2 inhibition on formalin-evoked nociceptive behaviour and prostaglandin E2 release in the spinal cord

Irmgard Tegeder, Ellen Niederberger, Gregor Vetter, Lutz Bräutigam, Gerd Geisslinger

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 1.82 MB

english, 2001

36

Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein

Jörn Lötsch, Rodolfo Schmidt, Gregor Vetter, Helmut Schmidt, Ellen Niederberger, Gerd Geisslinger, Irmgard Tegeder

Journal:

Journal of Neurochemistry

Year:

2002

Language:

english

File:

PDF, 303 KB

english, 2002

37

Protein associated with Myc (PAM) is involved in spinal nociceptive processing

Corina Ehnert, Irmgard Tegeder, Sandra Pierre, Kerstin Birod, Hong-Van Nguyen, Achim Schmidtko, Gerd Geisslinger, Klaus Scholich

Journal:

Journal of Neurochemistry

Year:

2004

Language:

english

File:

PDF, 484 KB

english, 2004

38

Cyclooxygenase-1-Coupled Prostaglandin Biosynthesis Constitutes an Essential Prerequisite for Skin Repair

Kämpfer, Heiko, Bräutigam, Lutz, Geisslinger, Gerd, Pfeilschifter, Josef, Frank, Stefan

Journal:

The Journal of Investigative Dermatology

Year:

2003

Language:

english

File:

PDF, 2.90 MB

english, 2003

39

The role of cGMP and PKG-I in spinal nociceptive processing

Achim Schmidtko, Irmgard Tegeder, Ellen Niederberger, Franz Hofmann, Peter Ruth, Gerd Geisslinger

Journal:

BMC Pharmacology

Year:

2005

Language:

english

File:

PDF, 205 KB

english, 2005

40

Cysteine-rich protein 2 is a downstream effector of cGMP-dependent protein kinase I in nociception

Achim Schmidtko, Wei Gao, Matthias Sausbier, Inga Grundei, Ellen Niederberger, Klaus Scholich, Andrea Huber, Hans-Dieter Allescher, Franz Hofmann, Peter Ruth, Gerd Geisslinger

Journal:

BMC Pharmacology

Year:

2007

Language:

english

File:

PDF, 182 KB

english, 2007

41

cGMP-dependent signaling pathways in spinal pain processing

Achim Schmidtko, Wei Gao, Peter König, Sandra Heine, Matthias Sausbier, Peter Ruth, Doris Koesling, Irmgard Tegeder, Andreas Friebe, Gerd Geisslinger

Journal:

BMC Pharmacology

Year:

2009

Language:

english

File:

PDF, 70 KB

english, 2009

42

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation

Brenneis, Christian, Sisignano, Marco, Coste, Ovidiu, Altenrath, Kai, Fischer, Michael J, Angioni, Carlo, Fleming, Ingrid, Brandes, Ralf P, Reeh, Peter W, Woolf, Clifford J, Geisslinger, Gerd, Scholic

Journal:

Year:

2011

Language:

english

File:

PDF, 846 KB

english, 2011

43

Higher pain scores, similar opioid doses and side effects associated with antipyretic analgesics in specialised tertiary pain care

Jörn Lötsch, Rainer Freynhagen, Nils von Hentig, Norbert Griessinger, Michael Zimmermann, Reinhard Sittl, Gerd Geisslinger

Journal:

Inflammation Research

Year:

2010

Language:

english

File:

PDF, 288 KB

english, 2010

44

Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations

Svenja D. Steinbrink, Carlo Pergola, Ulrike Bühring, Sven George, Julia Metzner, Astrid S. Fischer, Ann-Kathrin Häfner, Joanna M. Wisniewska, Gerd Geisslinger, Oliver Werz, Dieter Steinhilber, Thorste

Journal:

Cellular and Molecular Life Sciences

Year:

2010

Language:

english

File:

PDF, 336 KB

english, 2010

45

The effects of COX-2 selective and non-selective NSAIDs on the initiation and progression of atherosclerosis in ApoE−/−mice

Julia Metzner, Laura Popp, Claudiu Marian, Ronald Schmidt, Christine Manderscheid, Christoph Renne, Beate Fisslthaler, Ingrid Fleming, Rudi Busse, Gerd Geisslinger, Ellen Niederberger

Journal:

Journal of Molecular Medicine

Year:

2007

Language:

english

File:

PDF, 489 KB

english, 2007

46

Cellular membranes function as a storage compartment for celecoxib

Thorsten J. Maier, Susanne Schiffmann, Ivonne Wobst, Kerstin Birod, Carlo Angioni, Marika Hoffmann, Jakob J. Lopez, Clemens Glaubitz, Dieter Steinhilber, Gerd Geisslinger, Sabine Grösch

Journal:

Journal of Molecular Medicine

Year:

2009

Language:

english

File:

PDF, 347 KB

english, 2009

47

Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences?

Irmgard Tegeder, Gerd Geisslinger

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2006

Language:

english

File:

PDF, 350 KB

english, 2006

48

Rapid genotyping for relevant CYP1A2 alleles by pyrosequencing

Carsten Skarke, Anja Kirchhof, Gerd Geisslinger, Jörn Lötsch

Journal:

European Journal of Clinical Pharmacology

Year:

2005

Language:

english

File:

PDF, 258 KB

english, 2005

49

Induction of apoptosis in human prostate stromal cells by 4-hydroxytamoxifen: an alternative therapy for benign prostate hyperplasia

Wolfgang Glienke, Yuliya Dolgova, Iris Müller, Sabine Grösch, Jochen Binder, Gerd Geisslinger, Dietger Jonas

Journal:

World Journal of Urology

Year:

2004

Language:

english

File:

PDF, 299 KB

english, 2004

50

The S1P2receptor expressed in human platelets is linked to the RhoA-Rho kinase pathway and is down regulated in type 2 diabetes

Voahanginirina Randriamboavonjy, Klaus Badenhoop, Helmut Schmidt, Gerd Geisslinger, Beate Fisslthaler, Ingrid Fleming

Journal:

Basic Research in Cardiology

Year:

2009

Language:

english

File:

PDF, 335 KB

english, 2009

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